- Research
- RAMS
- Federal Programs
- RFFR
- International Projects
- Initiative Developments
The research is carried out at the Institute in the frames of government contracts of Federal Agency on Science and Innovationsand Federal Space Agency, fundamental topics of the Russian Academy of Medical Sciences, grants from the Russian Foundation for Basic Research.
Main tendencies of research carried out at the Institute are determined by high-throughput postgenomic and bioinformatic technologies, along with hig-precision analytical methods, based on nanotechnologies.
Fundamenral research is carried out in the frames of inter-agency research program "proteomics in Medicine and biotechnology", and aimed at creation of brand new diagnostic systems in the field of infection diseases (HIV, Hepatites B and C), oncological diseases (prostate cancer, ovarian carcinoma, liver cancer, mechanism of metastasis), and neurogenerative disease (Alzheimer's disease).
The R&D project in the field of applied science is aimed on creation of universal drug delivery system in the organism. The project is ordered by Federal agency on Science and Innovations. Through the embedding of drugs, primarily antitumoral ones, into phospholipid nanoparticles, their therapeutic efficacy could be essentially increased, and the side-effects could be reduced. The universalism of the system will led not only to creation of more effective antitumoral drugs within the nearest 5 years, but also medications for rheumatoid arthritis, bronchial asthma, cardiovascular system disease, antiphlogistic and antibicrobic drugs.
| Structure of the realized themes in 2007 |
Foundation | Quantity | Resourse* |
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1.Program «Proteomics and bioinformatics in medicine» RAMS | 5 | 20% | 2. Plan's themes RAMS | 14 | 15% | 3. Complex projects of R&D | 1 | 36% | 4. Contracts of R&D | 2 | 5% | 5. Contracts | 4 | 7% | 6. Grants of RFPF | 10 | 12% | 7. International grants and contracts | 4 | 8% | 8. Enterprising development | 4 | 5% |
*Percentage share in the annual budget.
Russian Academy of Medical Science provided additional financing to support innovation developments in the area of nanobiotechnologies and computer drug design.
| Nanotechnology for medical diagnostics | This project is aimed to develop effective methods to diagnose viral infections. Atomic force microscopy devices and optical biosensors are widely used to register individual molecular complexes which indicate viral particles or antigens present in patient's blood. It has been planned to use register devices based on standard driver to read compact disks (CD-Rom). |
| Experimental computing program "from Genome to Drug" | This project is aimed to develop software and hardware-based devices to realize the whole cycle of new drug developments. The conception of proposed method is based on revelation of interacting proteins, makin complexes. Such complex is considered to be a molecular target for new drugs prototypes.
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Institute participates actively in competitions to be available to investigate in the frames of Federal Principle Scientific-Technical Program on 2002-2006. In 2005 stuff of the institute is conducting the works on 6 government contractual work, Research Institute of Biomedical Chemistry is the main performer of 2 of them:
| Biosensoric devices with direct detection for medical diagnostics |
Priority directions: "Living Systems"
Deadline: 2005
Performers: Nanobiotechnology laboratory
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| SDC development "Postgenomic Technologies Center" |
Priority direction: Infrastructure Development
Scientific subjects-matter: Clinical Proteomics
Deadline: 2005-2006
Performers: Proteomic Research Department
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| Vaccine development against hepatitis B and C (co-performers) |
Priority direction: "Living systems"
Deadline: 2005
Performers: Protein Engineering Laboratory
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| Support of leading scientific schools |
Priority directions: "Living Systems"»
Scientific subject-matter: development of methods for determination of toxicity
Deadline: 2005
Performers: microsomal oxidation laboratory
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| Development of web-oriented system for molecular doking |
Priority direction: "Bioinformational Technologies"
Deadline: 2005-2006
Performers: Bioinformational technologies laboratory
In 2005 scientific works have been conducted on 6 projects, supported by Russian Fund of Fundamental research. 5 projects, submitted in 2005 acquired support. One of them is innovate. Innovation project is directed on the development of new generation antimetastatic drugs. Deadline 2005-2007.
In 2005 researches of 8 Institute's laboratories submitted more than 10 projects. In 2004-2005 an average level of Institute's projects support in the frames of RFFR is 22%.
RFFR's requests are mostly directed on the following area of knowledge:
Biology and medical science - Proteomics, structure and protein function;
- Biochemistry
- Medical chemistry, pharmacology
Creation and development of ICTR for fundamental research
| ISTC Grants | - industrial technology development of substance production; creation of drug form samples; substance preclinical trials; structural, functional study and production of modified forms with recombinant L-asparaginase Erwinia carotovora advanced pharmacological qualities;
- computer searching of HIV-1 integrase inhibitors. |
| INTAS Grants | - study of protein-protein interaction in Cytochrome P450-containing monooksigenase systems at the hydroxyling conditions;
- mammals cellular cycle modeling of norma and pathology to predict potentially antitumoral compounds affecting on key targets. |
| Wellcome Trust Grants | - Isatin binding proteins proteome analysis. |
| Cooperation | - agreement on scientific cooperation with Janssen Pharmaceutics;
- agreement on software development to analyze time-of-flight mass-spectrometry data ("Bruker Daltonics")
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| Methods of system biology in proteomics |
Statistical algorithm is being developed, it will give an opportunity to conduct complex analysis of 2D image electrophoregam. As a result, interacting proteins net is built based on revealed correlative changes on the expression level, Ph and molecular mass. This method is being tested on the model of stem cell differentiation.
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| Quantative method of proteomic analysis |
| Matrix and electrosprey ionization potentials are analyzed in the light of their application to receive quantative characteristics of protein content in the sample. As basic data, chromatografical pikas, pikas on mass chromatogram and pikas on mass-spectrum MALDI appear. |
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