|
Russian Journal | ISSN 0042-8809 |
| Voprosy Meditsinskoi Khimii | Biomedical Chemistry |
Issue:
Volume 49, issue 1
Title: EARLY PROTEOMICS OF OVARY CANCER: MYTH OR REALITY
Authors: O. V. Makarov1, V. M. Govorun2, I. N. Taranets1, E. I. Goufman2, A. N. Gritsai3, A. I. Archakov2
Address:
1Russian State Medical University, Moscow
2Institute of Biomedical Chemistry Russian Academy of Medical Sciences 10 Pogodinskaya str., Moscow, 119121 Russia; fax:(095)245-0857
3Russian Research Centre for Oncology Russian Academy of Medical Sciences
Abstract:
Literature data summarizing new approaches and importance of early ovary cancer diagnostics have been reviewed. Alpha-feta-protein (AFP) and SA125 were the most reliable markers for determination of early ovary cancer stages. Nevertheless, these markers don't reflect the disease stage, malignance and they don't possess sufficient specificity. New methodical approaches have recently been introduced. They include combination of 2-D electrophoresis with mass-spectrometry. These methods allow to inventory and identify almost all proteins of various tissues. Using these methods for scanning proteins from biopsies of ovary cancer tissues new markers have been discovered.
Key words: ovary cancer, 2D-electrophoresis, mass-spectrometry, marker proteins.
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