Russian Journal
|
Russian Journal |
ISSN 0042-8809 |
| Biomeditsinskaya Khimiya | Biomedical Chemistry |
Issue:
Volume 49, issue 3
Title: COMPUTER MODELLING OF 3D STRUCTURE OF CYTOCHROMES Ð450: PROBLEMS AND FUTURE TRENDS
Authors: A.S.Ivanov, V.S.Skvortsov, À.À.Sechenykh, À.V.Dubanov, À.V.Lisitsa
Address:
Orekhovich Institute of Biomedical Chemistry of Russian Academy of Medical Sciences, Pogodinskaya str. 10, Moscow, 119121, Russia; fax: (095) 245-0857; e-mail: ivanov@ibmc.msk.ru;
Abstract:
The review is devoted to the description of basic approaches, problems and prospects of computer modelling of 3D structures of cytochromes Ð450 (Ð450s). The following questions hawe been are considered in review: (1) the role of computer molecular modelling in Ð450s research; (2) basic stages of homology modelling of protein 3D structures; (3) purposes and tasks of molecular modelling; (4) problems of P450s homology modelling; (5) criteria for successful Ð450s homology modelling; (6) methods of Ð450s models refinement, verification of correctness and reliability.
Key words: cytochrome Ð450, computer molecular modelling, homology modeling.[Back]