Authors: V.P. Chekhonin, A.V. Semenova, O.I. Gurina, T.B. Dmitrieva

Address: Serbsky National Research Centre For Social and Forensic Psychiatry. 23 Kropotkinsky Per., Moscow, 119992 Russia

Abstract:

Myelin oligodendrocyte glycoprotein (MOG) is a myelin-specific protein of the central nervous system (CNS). It is a member of the immunoglobulin superfamily. The contents of this protein in oligodendrogliocyte membrane is very low (approximately 0.1% total proteins). functions of MOG are still unknown. It is considered that MOG is an autoantigen capable to produce a demyelinating multiple sclerosis-like disease in experimental animals. The structure, membrane topology, putative functions and role in demyelinating diseases are considered in this review.

Key words: myelin oligodendrocyte glycoprotein (MOG), myelin, genom, complement, immune response, demyelination

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