Russian Journal
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Russian Journal |
ISSN 0042-8809 |
| Biomeditsinskaya Khimiya | Biomedical Chemistry |
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Issue:
Volume 50, issue 3
Title: The Influence of Nitric Oxide Generation on the Production of Interleukins and Processes of Prostaglandins Synthesis in Fetal Membranes in Spontaneous Parturition and Uterine inertia
Authors: I.I. Krukier, T.N. Pogorelova, A.V. Orlov
Address: Rostov Institute for Obstetrics and Gynecology, Mechnikova 43, fax: (863-2) 32-57-63; å-mail: biochem@rniiap.ru
Abstract:
62 women in 38-40 weeks gestation were examined, 37 of them had normal delivery, whereas others (25) with uterine inertia, had delivery by Cesarean section. In the fetal membranes preparations nitric oxide production, interleukins -1b and -6, arachidonic acid content and phospholipase A2 activity (limiting the rate of prostaglandin biosynthesis) were examined. In the case of uterine inertia increase of nitric oxide generation, decrease of interleukins and arachidonic acid levels and phospholipase A2 activity was found. Modulation of nitric oxide production with inhibitors and activators allowed to emphasize the role of NO in regulation of cytokine response and control of initial stages of prostaglandins synthesis.
Key words: nitric oxide, interleukins, prostaglandins synthesis, fetal membranes, uterine inertia.
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