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Russian Journal

 ISSN 0042-8809
Biomeditsinskaya Khimiya

Biomedical Chemistry

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Issue:
Volume 51, issue 3

Title:CIRCULATING NUCLEIC ACIDS IN BLOOD OF PATIENTS WITH MALIGNANT TUMORS OF GASTROINTESTINAL TRACT

Authors: S. N. Tamkovich1, O. E. Bryzgunova1, E. Yu. Rykova1, E. V. Kolesnikava2, P. I. Shelestuk2, P. P. Laktionov1, V. V. Vlassov1

Address:

1Institute of chemical Biology and Fundamental Medicine SB of RAS, Lavrentiev ave. 8, Novosibirsk, 630090 Russia; tel.: 7(383-2) 30-46-54, fax: 7(383-2) 33-36-77
2Novosibirsk Oncological Dispensary, Plachotnogo ave., 2, Novosibirsk, 630108 Russia

Abstract:

Concentrations of extracellular deoxy- and ribonucleic acids in blood plasma and cell-surface-bound of blood cells were investigated in healthy donors and patients with malignant gastrointestinal tumor. Our results indicate that high concentration of extracellular DNA in blood plasma along with decreased level of extracellular RNA on the surface of blood cells correlate with development of gastrointestinal cancer. Ratio of nucleic acids in plasma to total amount of nucleic acids circulated in blood is a characteristic parameter distinguishing cancer patients healthy persons.

Key words: blood plasma, blood cells, extracellular nucleic acids, cell-surface-bound nucleic acids, stomach cancer, colorectal cancer

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