Russian Journal

ISSN 0042-8809

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Issue:
Volume 51, issue 6

Title:INFLUENCE OF L-ARGININE AND INHIBITORS OF NO-SYNTHASE ON GENERATION OF NITRIC OXIDE AND NITROSOTHIOLS AT TOXIC DAMAGE OF LIVER

Authors: G. N. Bliznetsova, S. S. Artemieva, M. I. Retsky

Address:

Abstract: The effects of L-arginine and inhibitors of NO-synthase on the level of stable NO metabolites and nitrosothiols have been investigated under conditions of toxic damage of liver induced by CCI₄. The L-arginine improved resistance of hepatic cells to damaging action of tetrachloromethane, but inhibition of NO-synthase increased hepatotropic action of CCI₄. The existence of some base level of nitrosothiols, acting as a reserve pool of nitric oxide in organism, has been supposed.

Key words: toxic damage of liver, nitric oxide, nitrosothiols

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