Russian Journal

ISSN 0042-8809

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Issue:
Volume 53, issue 2

Title: STUDY OF SUBSTRATE SPECIFICITY OF A NEW PEPTIDE SUBSTRATE OF ENDOTHELIN CONVERTING ENZYME

Authors: T.A. Gureeva, E.V. Eugaevskaya, V.F. Pozdnev, V.N. Prozorovskiy, Yu.E. Alisseeva, N.I. Solovyeva

Address: Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Pogodinskaya St., 10, Moscow, 119992 Russia; tel. (495)2465072, e-mail: Nina.Solovyeva@ibmc.msk.ru

Abstract:

The new fluorogenic hexapeptide substrate CMC-Ala-Gly-Gly-Trp-Phe-Arg was used as substrate for endothelin-converting enzyme (ECE), angiotensin-converting enzyme (ACE) and neutral endopeptidase (NEP). The specific inhibitors lisinopril (ACE) and thiorphan (NEP) were used for identification of  these enzyme activities.

Key words:CMC hexapeptide, endothelin-converting enzyme, angiotensin-converting enzyme, neutral endopeptidase, inhibitors.

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