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Issue:
Volume 53, issue 2

Title: THE ABILITY OF BACTERIAL DNA METHYLTRANSFERASES TO USE METHYLCOBALAMINE AS A COFACTOR IN DNA METHYLATION REACTIONS

Authors: A.Yu. Lebionka, V.I. Melvidas

Address: Laboratory of Genetics, Institute of Botany, Zaliuju ezeru 49, Vilnius, Lithuania, tel.: +370 5 271 1618; fax: +370 5 272 9950; e-mail: SKS@erdves.lt

Abstract:

The ability of bacterial DNA methyltransferases Alu I, Cfr I, Cfr 6, Cfr 10, Eco RI, Eco RII, Msp I, Mva I, Pvu I, Pvu II, and Sau 3A to use methyl-cobalamine and methyl-methionine as cofactors of DNA methylation in vitro. These bacterial DNA methyl transferase used methyl-cobalamine, but not methyl-methionine for DNA methylation.

Key words: methylcobalamine, methylmethionine, DNA methylation.

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