Russian Journal

ISSN 0042-8809

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Issue:
Volume 53, issue 3

Title: PARAMETERS OF PLASMA BLOOD PROTEOLYSIS AND PHENOTYPES OF α₁-PROTEINASE INHIBITOR IN CHILDREN WITH DUODENAL ULCER

Authors:O.E. Akbasheva.

Address: Departments of Biochemistry and Molecular Biology, Siberian State Medical University,Moskovskiy tract 2, Tomsk, 634050 Russia; tel.: (3822) 53-04-23, e-mail: akbaseva@ssmu.net.ru

Abstract:

The aim of this study was to determine correlation between proteolysis parameters and phenotypes of α₁-proteinase inhibitor in blood plasma in children with duodenal ulcer. Activation of pepsin- and trypsin like proteinases was accompanied by the decrease in activity of α₂-macroglobulin and the increase in activity of acid stable inhibitors. The phenotypes М₁М₃, М₁М₁, М₂М₂ of α₁-proteinase inhibitor were determined. Activation of proteolysis was more pronounced in individuals with subtype М₂М₂. Activity of α₁-proteinase inhibitor decreased by 2-fold in М₂М₂, insignifically differed from the control group in М₁М₁, and increased by 1,9-fold in М₁М₃ subtype. Low activity of α₁-proteinase inhibitor was accompanied by high activity of acid stable inhibitors; this may be regarded as the protective reaction of the body. Determination of α₁-proteinase inhibitor phenotypes may be a basis for employment of polyvalent proteinase inhibitors for therapy of ulcer.

Key words: proteinases, phenotypes of α₁-proteinase inhibitor, acid stable inhibitors,                       α₂-macroglobuline, duodenal ulcer..

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