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Russian Journal |
ISSN
0042-8809 |
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Biomeditsinskaya Khimiya |
Biomedical Chemistry |
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Issue:
Volume 53, issue 5
Title: NATRIURETIC PEPTIDES.
Authors: A.E. Medvedev1,2
Address:
1. Orekhovich Institute of
Biomedical Chemistry, Russian Academy of Medical Sciences, 10 Pogidinskaya
str., Moscow, 119121 Russia; e-mail: Alexei.Medvedev@ibmc.msk.ru;
2. Moscow Medical Dental University,
Moscow, Russia
Abstract:
Natriuretic peptides are
the family of structurally related peptides involved into regulation of volume and blood pressure, water and
electrolyte metabolism, and also cell proliferation. Their effects are mediated
via three types of membrane receptors. Two of them are receptor guanylate
cyclases, which catalyze cGMP
formation (from GTP), second intracellular messenger responsible for
realization of regulatory signals
of these hormones. Genetic defects resulting in deficit of natriuretic peptides
or their functionally active receptors in transgenic mice cause development of
arterial hypertension, myocardial hypertrophy and increased mortality in early
age.
Key words: natriuretic
peptides, ANP, BNP, CNP, receptors, receptor guanylate cyclase, biomedical
importance.
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