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Russian
Journal
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ISSN
0042-8809
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Biomeditsinskaya
Khimiya
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Biomedical
Chemistry
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Issue:
Volume 54, issue 1
Title:STUDY MELATONIN
INFLUENCE ON FREE RADICAL HOMEOSTASIS IN RAT TISSUES AT THYROTOXICOSIS.
Authors: S.S. Popov1, A.N. Pashkov1,
T.N. Popova2, V.I. Zoloedov1, A.V. Semenikhina2,
T.I. Rakhmanova2.
Address:
1.Voronezh State
Medical Academy of N.N. Burdenko;
2.Voronezh
State University,
394006, Russia, Voronezh, Universitetskaya
sq., 1; tel.: (4732)208278; fax: (4732)208755; e-mail: tpopova@bio.vsu.ru
Abstract:
Experimental
thyrotoxicosis in rats is accompanied
by the increase of serum alanine
aminotransferase (AlA),
aspartate aminotransferase (AsA), creatine kinase-MB (CK-MB) activities and
content of primary products of lipid peroxidation - conjugated dienes - in
liver, heart and blood. This suggests impairments in these organs accompanying
free radical processes intensification. Administration of melatonin decreased AlA, AsA and CK-MB
activities and CD level decreased. Thyrotoxicosis increased catalase activity
in liver, heart and blood. Exogenous melatonin decreased specific activity of
catalase in blood and in heart in comparison with animals subjected to
hyperthyroidism. However, some increase of catalase specific activity
(~15%) was observed in liver. a-Tocopherol content, raising in rat tissues in
thyrotoxicosis development conditions, decreased after melatonin treatment.
Thus, exogenous melatonin is capable to reduce lipid peroxidation intensity at
thyrotoxicosis and to act as an adoptogen, regulating free radical
homeostasis.
Key words: thyrotoxicosis, melatonin, free radical
homeostasis, catalase, a-tocopherol.
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