Russian Journal

ISSN 0042-8809

 

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Issue: Volume 54, issue 2

Title: CYSTATINS: CYSTEINE PROTEASES REGULATION AND DISTURBANCES IN TUMORS AND INFLAMMATION.

 

Authors: T.A. Korolenko¹, T.G. Filatova¹, M.S. Cherkanova², T.A. Khalikova¹, I.Yu. Bravve².

 

Address:

1. Institute of Physiology Siberian Branch of Russian Academy of Medical Sciences, Timakov str., 4, Novosibirsk, 630117 Russia;

2. Novosibirsk Regional Cardiology Unit, Novosibirsk, 630099 Russia; e-mail: T.A.Korolenko@iph.ma.nsc.ru.

 Abstract:

Cystatin C belongs to the group of wide spread extracellular cysteine protease inhibitors. Using ELISA kits it was shown that the highest cystatin C concentration was in human cerebrospinal fluid and low cystatin C concentration was in human urine. In healthy young persons serum cystatin C concentration was lower than in elder patients (50-65 year old). In patients with hemoblastoses (lymphoma, lymphogranulomatosis) increased serum cystatin C concentration was normalized after effective antitumor therapy. According to these data one can conclude that serum cystatin C concentration can be used as one of the prognostic criteria in patients with several kinds of hemoblastoses.

Key words: cystatins, cysteine proteases, tumors, atherosclerosis.

 

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