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Issue: Volume 55, issue 1

Title: REDUCED GLUTATHIONE INTERACTION WITH THIOPHOSPHORIC DERIVATIVES OF ALKALOIDS OF CHELIDONIUM MAJUS L. IN VITRO

Authors: A. Glazev, L. Nefyodov

Address:

Laboratory of Biochemistry of Biologically Active Substances Yanka Kupala State University of Grodno, Belarus, 52, BLK, Grodno, 230017 Belarus, tel./fax: +375 (152) 48 75 41; tel. +375 (29) 63 76 982; e-mail: l.nefyodov@grsu.by, www.nil.grsu.by

Abstract:

    The interaction between reduced glutathione and thiophosphoric derivatives of alkaloids of greater celandine was studied by the photometric method of analysis and fluorescence spectroscopy in vitro. Results demonstrate possibility of specific interaction between reduced glutathione and thiophosphoric derivatives of alkaloids.
    It is possible that similar interaction of thiophosphoric derivatives of alkaloids may involve SH�groups of amino-acid residues, at the active sites of some metabolic enzymes.

Key words: reduced glutathione, thiophosphoric derivatives of alkaloids, effect of extinguishing of fluorescence.

Biomedical Chemistry, 2009 Volume 55, Issue 1, p. 114-120.

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