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Issue: Volume 55, issue 3

Title: METABOLIC FINGERPRINTING OF BLOOD PLASMA FOR PATIENTS WITH PROSTATE CANCER

Authors: P.G. Lokhov, M.I. Dashtiev, L.V. Bondartsсov, А.V. Lisitsa, S.A. Moshkovskii, A.I. Archakov

Address:

Institute of Biomedical Chemistry RAMS, Pogodinskaya st.10, Moscow, 119121 Russia; e-mail: lokhovpg@rambler.ru

Abstract:

    Application of blood plasma metabolites fingerprinting for the diagnostic of the 2nd stage of prostate cancer has been investigated. The diagnostic sensitivity (95%), specificity (96,7%) and accuracy (95,7%) of the metabolic fingerprinting were much higher then those for PSA test (35%, 83,3% and 51,7%, respectively) for the same patients. Area under the ROC-curve (0,994) suggests that the proposed approach is effective and can be used for clinical applications.

Key words: metabolomics, metabolic fingerprinting, mass spectrometry, prostate cancer.

Biomedical chemistry 2009 Volume 55, Issue 3, p. 247-254.

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