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Issue: Volume 55, issue 3

Title: GLUTATHIONE SYSTEM I. SYNTHESIS, TRANSPORT, GLUTATHIONE TRANSFERASES, GLUTATHIONE PEROXIDASES

Authors: V.I. Kulinsky, L.S. Kolesnichenko

Address:

Departments of Biochemistry1 and Biononorganic and Bioorganic Chemistry2, Irkutsk State Medical University, Irkutsk, Russia; tel.: (395)224-0826; e-mail: kulinsky@pp.irkutsk.ru

Abstract:

Studies of glutathione system in all basic trends have been extended considerably during recent 10-15 years. A series of new metabolic enzymes has been discovered. Many of them are polyfunctional and their new activities have been recognized. The enzymes interact with hormones and signal transduction systems. The studies of intracellular, intercellular and inter organs transports have been considerably advanced. The important achievement consist in unmasking new functions not only by selective substances-analytics but also by gene engineering methods as well.

Key words: glutathione, metabolism enzymes, regulation.

Biomedical Chemistry, 2009 Volume 55, Issue 3, p.255-277.

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