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Issue: Volume 55, issue 3

Title: EXTRACTION EFFECT OF ULTRASOUND DURING PLASMA CLOT DISRUPTION

Authors: Е.А. Cherniavsky¹, I.E. Adzerikho², V.M. Shkumatov¹

Address:

¹Research Institute for Physical Chemical Problems of the Belarusian State University, Leningradskaya Str., 14, Minsk, 220030 Belarus; tel./fax: (+375 17) 209-5461; e-mail: biopharm@bsu.by

Abstract:

    The products of plasma clot destruction by the low-frequency ultrasound (US) were analyzed by the combination of SDS gel-electrophoresis, gel filtration chromatography and scanning electron microscopy. It was found that US (27 kHz) did not cause activation of the plasmin system or covalent bonds cleavage in the fibrin molecules. With the US intensities less than 21.6 W/cm² the extraction of blood serum proteins, which are located in the pores of the fibrin network was occurred. An increase of the intensity of ultrasonic action led to protofibril dissociation, which was accompanied by further release into the solution of the blood serum proteins located inside the fibrin fibers. Being extracted from aggregated plasma clot proteins free protofibrils formed insoluble fibrin particles.

Key words: ultrasound, plasma clot, fibrin, thrombolysis.

Biomedical Chemistry, 2009 Volume 55, Issue 3, p.298-309.

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