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Issue: Volume 55, issue 5

Title: PROTEOLYTIC ACTIVITY OF PLACENTA WITH EPH-GESTOSIS

Authors: O.P. Petrushova, M.T. Gengin, V.A. Smetanin, A.V. Kuznetsova

Address:
Department of Biochemistry Penza State Pedagogic University, Penza State University; tel.: 8(8412)562566, 8(8412)478570; e-mail: chorion@rambler.ru

Abstract:

Essential edema-proteinuria-hypertension (EPH) gestosis still represents an important obstetrical problem. We have investigated the activity of carboxypeptidase Н (CPН), phenylmethylsulfonyl fluoride inhibited carboxypeptidase (PMSF-CP), carboxypeptidase M (CPM) and angiotensin-converting enzyme (ACE), the main carboxypeptidases in human placenta under normal conditions and mild EPH-gestosis. Gestosis was accompanied by the decrease in activity of the enzymes involved into metabolism of regulatory peptides (ACE, CPH, PMSF-CP, CPM) compared with their activity in placenta under physiological pregnancy. Correlation analysis revealed positive correlation between placental CPH and CPM (r = 0.2735*) in EPH-gestosis. These findings suggest involvement of placental proteases into formation of compensatory-adaptive reactions in the fetoplacental complex at EPH-gestosis; the data obtained may be also employed for the development of methods of prophylaxis and corrections of metabolic impairments in pathology of pregnancy.

Key words: placenta, fetoplacental complex, EPH-gestosis, carboxypeptidase, angiotensin-converting enzyme.

Biomedical Chemistry, 2009 Volume 55, Issue 5, p. 673-680.

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