Russian Journal

ISSN 0042-8809

Home  ׀  Editorial Board ׀  International Advisory Board  ׀  Aim and Scope ׀   Contents and Abstracts  ׀  Information for Authors ׀  Subscribe Now

Issue: Volume 55, issue 5

Title: THE INFLUENSE OF GUANIDINE DERIVATIVES ON FREE RADICAL OXIDATION INTENSITY AND ACONITASE ACTIVITY AT DEVELOPMENT OF BRAIN ISCHEMIA-REPERFUSION AT RATS

Authors: А.V. Makeeva¹, T.N. Popova¹, A.I. Slivkin², D.V. Krylsky²

Address:
¹Department of Medical Biochemistry and Microbiology, Biology and Soil Science Faculty;
²Department of Pharmaceutical Chemistry and Technology, Pharmaceutical Faculty, Voronezh State University, Universitetskaya sq., 1, Voronezh, 394006 Russia; tel.: (4732) 208-278; fax: (4732) 208-755; e-mail: makeeva81@mail.ru

Abstract:

The study of some guanidine derivatives influence on free radical oxidation intensity and aconitase activity during the development of brain ischemia-reperfusion at rats has been carried out. The biochemiluminescence parameters increasing at the brain pathology changed toward normal values under the influence of N-[4-(chlorbenzoyl)benztiazol-2-yl]guanidine, N-[imino(1-piperidinyl)methyl]guanidine and N-[imino(4-morpholinyl)methyl]guanidine. The aconitase specific activity decreased in brain and blood of animals with ischemia-reperfusion. Administration of guanidine derivatives during brain ischemia-reperfusion development increased aconitase specific activity. These results suggest that investigated substances can play a role of neuroprotectors, preventing free radical oxidation development.

Key words: brain, ischemia-reperfusion, guanidine derivatives, free radical oxidation, aconitase.

Biomedical Chemistry, 2009 Volume 55, Issue 5, p. 643-650.

[Back]