Russian Journal
| |
Russian Journal |
ISSN 0042-8809 |
| Biomeditsinskaya Khimiya |
Biomedical Chemistry |
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Issue:
Volume 56, issue 2
Title: ROLE
OF THIOLDISULFID OF SYSTEM IN MECHANISM OF OXIDATIVE STRESS
Authors: V.V.
Kostyushov, I.I. Bokal
Military
medical clinical center of South region (Odessa), The Odessa national
university the name of I.I. Mechnikov, Pirogovskay street, 2, Military medical
clinical center of South region,
In the article general
conformities to law and features of violation of the thioldisulfid an redox
system of whey of blood are described for patients with the without a symptom
transmitter of HIV and manifestly forms AIDS. The role of her components is
grounded – general, protein and non protein –SH, –S–S– groups in the mechanism
of forming of oxidative stress and distress at HIV of infection. The clinic and
laboratory criterions of expressed of peroxides processes are specified on the
indexes of violation of redox transformations of –SH, –S–S– groups,
neutralization and utilization of MDA and stability of LPC in the whey of blood
at HIV of infection. Found out intercommunication between expressed of
violation of the studied indexes, oxidative stress and distress and features of
clinical flow of HIV of infection, allowed authors to attribute this pathology
to “free radical diseases”. In this connection, indicated analytic it is suggested
to use as additional biochemical markers of oxidative stress and distress, and
also for the ground of setting of antioxidants and their combinations in
complex prophylactic or therapeutic application at HIVof infection.
Biomedical Chemistry, 2010 Volume 56, Issue 2, p. 290-298.
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