Russian Journal

ISSN 0042-8809

Issue:
Volume 45, issue 4

Title: METABOLISM of ENKEPHALINS AT DIFFERENT FUNCTIONAL AND PATHOLOGY CONDITIONS OF THE ORGANISM

Authors: PANCHENKO L.F., MITIUSHINA N.V., FIRSTOVA N.V., GENGIN M.T.

Address: Research Institute for narcology Ministry of Public Health, Mogiltsevskiy per. 3, 121921, Moscow; fax (095) 241-09-81;

Department of Chemistry, Penza State Pedagogical University, Lermontova st. 37, 440026, Penza, fax (8412) 66-27-06.

Abstract:

The peculiarities of metabolism of enkephalins at different functional conditions of the organism, different pathology and at the influence of some extreme factors are considered. Some special attention is given to the problem of interrelation and interdependence of enkephalins with proteolytic enzymes, participating in their synthesis and degradation. It is concluded that the biological property of neuropeptides as well as their participation in different physiological and pathological conditions of the organism very much depend on the peculiarities of functioning of enzyme systems of metabolism of neuropeptides.

Key words:  neuropeptides, enkephalins, metabolism, processing, inactivation, proteolytic enzymes.

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