Russian Journal

ISSN 0042-8809

Issue:
Volume 45, issue 4

Title: Antioxidant properties of arbidol and its structural analogues

Authors: O.V. Vasiljeva, O.B. Lyubitsky¹, T.A. Guskova², R.G. Glushkov², O.S. Medvedev, Yu.A. Vladimirov¹

Address:

MV Lomonosov Moscow State University, Faculty of Basic Medicine, bld A, room. 1029, Moscow, 119899, Russia

¹Department of Biophysics, Russian State Medical University, Ostrovityanova ul. 1, Moscow, 117869, Russia

²Centre for Chemistry of Drugs, Zubovskaya str. 7, Moscow,119815, Russia

Abstract:

The effect of arbidol and its structural analogues on the process of lipid peroxidation in phospholipid liposomes induced by Fe²⁺ has been investigated. It was shown that the antioxidant efficacy of arbidol and its derivatives is lower than that of a -tocopherol by two or three times. It was suggested that the mechanism antioxidant action of the arbidol and its structural analogues consists of scavenging of lipid radicals rather than chelating of Fe²⁺.

Key words: lipid peroxidation, arbidol, antioxidants, chemiluminescence.

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