Russian Journal

ISSN 0042-8809

Issue:
Volume 45, issue 6

Title: COMMON PROPERTIES OF PHARMACOLOGICAL AGONISTS AND ANTAGONISTS OF EXTERNAL MEMBRANE RECEPTORS.

Authors: A.I. Luik¹, V.V. Prokopenko, V.Yu. Tanchuk, V.V. Kholodovich, I.V. Semenuta.
¹Author to whom correspondence should be addressed.

Address:
Institute of Bioorganic and petroleum chemistry of the National Academy of Sciences of Ukraine. Murmanskaya, 1253660 Kiev UKRAINE

Abstract:

Using experimental transcription model in vitro, and method of electron-topological calculations the elements of pharmacological and structural community have been found in the groups of physiologically active compounds (PAC) blocking and activating external cellular receptors. This finding confirms the necessity of subdivision special groups of bio-substrates blockators and activators for hierarchical classification, of PAC.

Key words: transcription in vitro, structure-activity relationship, electron topological method

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