Russian Journal

ISSN 0042-8809

Issue:
Volume 46, issue 1

Title: VITAMIN B-6 METABOLISM IN PHENYLKETONURIC PATIENTS

Authors: L.A.Kharitonchik, V.M.Kodentsova, O.A.Vrzhesinskaya, S.N.Denisova, V.B.Sprichev

Address:
Institute of Nutrition at Russian Medical Academy, Moscow, fax (095)298-1855

Abstract:

Based on the analysis of the dependence of 4-pyridoxic acid urinary excretion from pyridoxal-5'-phosphate blood plasma level and its statistic distribution it has been shown that vitamin B-6 metabolism in children suffering from phenylketonuria and therefore the criteria of the body saturation with this vitamin differ from those for healthy people. Increased pyridoxal-5'-phosphate blood plasma level has been demonstrated for PKU children. The concentration of 11 ng/ml shoud be considered as a bottom border of the adequate supply with vitamin B-6. The elevated vitamin B-2 intake approximates vitamin B-6 status indexes of sick children to those usually measured in healthy children. The necessity for the reevaluation of vitamin B-2 and B-6 optimal diet content under this disease and its biochemical validation are discussed.

Key words: Vitamin B-6, vitamin B-2, criteria of vitamin supply

[Back]