Russian Journal

ISSN 0042-8809

Issue:
Volume 46, issue 2

Title: LEUKOCYTE ELASTASE IN PLASMA OF PATIENTS WITH PULMONARY TUBERCULOSIS AND ITS PART IN BLOOD COAGULATION DISTURBANCES

Authors: V.L. Dotsenko¹, A.Ya. Spirina², A.I. Makinsky², E.A. Neshkova¹, Yu.E, Yorshikova¹, G.A.Yarovaya¹

Address: ¹ Russian Medical Academy for Postgraduate Education, Dept. of Biochem., Barrikadnaya, 2, Moscow 123836. Tel/fax: (095) 945 24 15, e-mail: acadbio@orc.ru

² Research Institute for Phthisiopulmonology, Moscow Medical I.Sechenov’s Academy, ul. Dostoyevsky, 4, Moscow 103030. Tel: (095) 281 96 03

Abstract:

53 patients with lung tuberculosis were divided in 3 groups in accordance with severety of disease. Leukocyte elastase, cationic proteins in neutrophils, activities of a ₁-proteinase and a ₂-macroglobulin were determined in patients’ plasma. Thromboelastographic, coagulating, fibrinolytic indices, and antithrombin III activity were also determined in 28 patients of all 3 groups.

Results demonstrated the high level of leukocyte elastase (6-fold more than normal) in plasma of patients with acute tuberculosis process. This group of patients demonstrated activation of intravascular coagulation proceeded on the background of significant decrease (up to 60%) of AT III activity. Conclusion: Acuity and severety of tuberculosis process in lung may be characterized by high activity of leukocyte elastase. Degranulating activity of neutrophils and releasing of elastase are the reason of AT III deficiency and increasing of intravascular coagulating activity in tuberculosis patients.

Key words: leukocyte elastase, tuberculosis, activation of neutrophils, inflammation, AT III deficiency, thrombohaemorrage complications

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