Russian Journal

ISSN 0042-8809

Issue:
Volume 46, issue 2

Title: THE INFLUENCE OF THYROXINE ON THE ENZYMES OF ENERGY METABOLISM IN BONE MARROW MYELOID CELLS AND NEUTROPHILS OF NEONATAL PIGLET

Authors: Babych N.O., Antonyak H.L., Tymochko M.F.

Address: Lviv State Medical University, Pekarska Str. 69, 290010 Lviv, Ukraine

Institute of Agriculture and Animal Biology, V.Stus Str.38, 290034 Lviv, Ukraine

Abstract:

The influence of thyroxine on the activities of enzymes of energy metabolism (hexokinase, 6-phosphofructokinase, pyruvate kinase, lactate dehydrogenase, glucose-6-phosphate dehydrogenase, NADP-isocitrate dehydrogenase, cytochrome c oxidase) was investigated in bone marrow myeloid cells and blood neutrophils of 3-10-day old neonatal piglets. Data obtained suggest different responsiveness of energy metabolism enzymes to thyroxine action. Repeated hormone injections resulted in the preferential stimulation of enzymes involved in oxidative stages of carbohydrate catabolysm in animal myelocaryocytes, while the activities of anaerobic enzymes in these cells were less affected. At the same time glycolytic enzymes in neutrophil granulocytes showed higher sensitivity to thyroxine action than enzymes catalyzing oxidative stages of energy metabolism.

Key words: thyroxine, energy metabolism, myeloid cells, leukocytes, neutrophylic granulocytes

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