Authors: I.L.Valuev, G.A.Sytov, L.I.Valuev, T.A.Valueva, M.V.Ul’yanova, N.A.Plate

Address: Topchiev Institute of Petrochemical synthesis, Russian Academy of Sciences, Leninsky prospekt 29, Moscow, 117912

Abstract:  

A new approach to overcome the degradation of insulin by proteolytic enzymes and its targeting to the blood through the digestive apparatus was developed. The approach is based on the immobilization of insulin into the polymeric hydrogel which is modified by ovomucoid - glycoprotein, inhibitor of proteolytic enzymes. Oral administration of this system to rabbits and rats, (in contrast to the hydrogels modified by proteolytic enzymes inhibitors without polysaccharide part), statistically significantly lowered blood glucose level.

Key words: diabetes mellitus, insulin preparation, ovomucoid modified  polyacrylamide.