Authors: L.V. Kozlov*, Т.А. Skirda, Т.G. Skorokhodova, V.М. Lakhtin, Т.N. Batalova, V.А. Guzova

Address: Gabrichevskii Moscow Research Institute  of Epidemiology and Microbiology, ul. Admirala Макаrоvа, 10, Moscow, 125212, Russia. Fax +7095-452-18-30. e-mail: l.v.kozlov@mtu-net.ru.

Abstract: 

The difference in the functional activity of the isotypes A and B of component C4 of human complement was used to determine their ratio to detect the inherited deficiency of the isotypes. The frequency of deficiency in healthy persons blood donors was equal for С4А and С4В (0.14 for each isotype), i.e. 14 % of total number (22) donors, or 28 % totally. These results agree with the literary data, on which the frequency of deficiency of С4А is 0,14, and of С4В is 0.11-0.16.

The inherent deficiencies of С4А and С4В for persons infected by Chlamydia were studied. For this purpose the patients (35 persons) with in blood antibodies (IgG or IgM) to  Chlamydia (C. trachomatis, C. psittaci and C. pneumoniae) were investidated. The frequencies of dificiency of С4А and С4В  were 0.29 and 0.46 respectively. Thus, the number of the undeficiencyt patients was only 25 %, while among healthy persons 70-75 % of individuals not having deficiencies of isotypes С4 were observed. The deficiencies of isotypes of С4 at this pathology is detected for the first time. The obtained data suggest the existenc of the predisposition to the development of diseases stipulated by Chlamydia in persons with inherent deficiency of  С4 component of  complement.

Key words: complement system, isotypes С4А and С4В, deficits, Chlamydia, ELISA.