Russian Journal

ISSN 0042-8809

Issue:
Volume 47, issue 2

Title: THE EFFECT OF ANTIBIOTIC THERAPY ON EMBRYOTROPIC ANTIBODIES IN WOMEN

Authors: S.G. Morozov^1,2, А.B. Poletaev³, V.Е. Radzinsky⁴, А.N. Protsenko⁴, D.A. Korgenevskii²

Address: ¹Municipal hospital №29 Committee for health, Moscow; ² Orekhovich Institute of Biomedical Chemistry RAMS; ³Fund Chernobyl-Test; ⁴Department of obstetrics and gynecology, Peoples Frendship University, Moscow

Embriotropic antibodies (e-Ab) serum contents were analysed in 29 serum samples obtained from women  suffering with primary lues. Before treatment the content of e-Ab against MBP, S100, ACBP14/18, and MP65 were markedly elevated in 28 samples. Two injections of Retarpen (2,5 mln Units with one week interval) were enough for effective treatment of lues.  At the same time treatment caused deep and reversible inhibition of  e-Ab production. One or two months later the levels of e-Ab returned to normal values in 21% of women, in 52% patients the hypoproduction, and in 27% the hyperproduction of e-Ab were noted. Deviations of e-Ab production after effective retarpen treatment suggest the existence of additional reasons which may influence e-Ab production, and necessity of additional diagnostic and curative measures for such women during pregravidal period.

Key words: embryotropic antibodies, antibiotic therapy, ELISA

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