|
Russian Journal | ISSN 0042-8809 |
| Voprosy Meditsinskoi Khimii | Biomedical Chemistry |
Issue:
Volume 47, issue 5
Title: ANTIOXIDANT ACTIVITY of NEW PROBUCOL ANALOGS AND THEIR INTERACTION WITH a-TOCOPHEROL
Authors: N.M. STOROZHOK1, A.P. KRISIN2, N.V. GUREEVA1
Address:
1 Tyumen State Medical Academy, 625023, Tyumen, st Odesskaya, 52, fax (3452) 22-62-00
2 Institute of Organic Chemistry SD RSA, 630090, Novosibirsk, av Lavrenteva, 9, fax(3832)34-47-52
Abstract:
The antioxidant and antiradical activities of sulfur ņontaining phenols which are analogues of probucol in comparison with a-tocopherol and BHT were tested using initiated methyl oleate oxidation model. The antioxidant effect linearly increased with increasing concentration of phenols. The ability of investigated phenols to destroy and reduced accumulation of hydroperoxides is revealed. The combined inhibitory effect of composition most effective researched antioxidant - CO-3 - with a-tocopherol for the first time are described.
Key words: a-tocopherol, substituted phenols, sulfurņontaining antioxidants
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