|
Russian Journal | ISSN 0042-8809 |
| Voprosy Meditsinskoi Khimii | Biomedical Chemistry |
Issue:
Volume 48, issue 4
Title: REGULATION OF SERUM CERULOPLASMIN ACTIVITY IN WOMEN WITH GYNECOLOGICAL TUMORS
Authors: Yu.N. Goussarova1, E. V. Stepanova2,
E.O.Landesman2, O.V.Koroleva2, T.P.Vavilova1, O.V.Makarov3,
V.N.Kosetsky3
Address:
1Moscow State Stomatological University, Moscow, tel.: (095)365-4597; E-mail: goussarova@yahoo.com
2Bakh Institute of Biochemistry, Russian Academy of Sciences, Moscow
3Russian State Medical University, Moscow.
Abstract:
Serum ceruloplasmin (CP) and anti-CP antibody levels were studied by the oxidase method in 18 healthy women and in 86 women with gynecological tumors. The results demonstrate that: 1) Serum CP concentrations increased in endometrial and ovarian cancer, in benign ovarian tumors and to a lesser extent in mioma of uterus. 2) Serum CP antibodies were found out in both benign tumors and cancer cases. 3) There was positive linear correlation betweenserum levels of CP and anti-CP-antibodies in endometrial and ovarian cancers, and in benign ovarian tumors.
Key words: ceruloplasmin, anti-ceruloplasmin antibodies, oncogynecological diseases.
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