|
Russian Journal | ISSN 0042-8809 |
| Voprosy Meditsinskoi Khimii | Biomedical Chemistry |
Issue:
Volume 48, issue 4
Title: THE LEVEL OF AUTOANTIBODIES AGAINST GLUTAMATE RECEPTORS SUBUNITS AND IMMUNOLOGICA PARAMETERS IN BLOOD OF EPILEPTIC PATIENTS
Authors: V.G.Bazarova, O.K.Granstrem, S.A.Dambinova
Address: Institute of Human Brain, Russian Academy of Sciences, 197386
St.-Peterburg, Pavlov st. 9
Abstract:
The role of glutamate receptors in the brain spiking activity was evaluated. The
electroencephalographic (EEG) spiking activity was monitored and autoreactive antibodies
(aAbs) to subunits of glutamate receptors were assessed in the blood serum of epileptic
and ischemic stroke patients. We showed that the level of GluR autoantibodies in blood
serum of patients correlates to the intensity of the brain paroxysmal activity. These data
confirm our previous observations. The level of GluR1 aABs has been proposed as a specific
biomarker typical for epilepsy. This approach could be recommended as an additional
criterion for diagnostic of nervous diseases such as epilepsy and ischemic stroke.
Key words: epilepsy, glutamate reseptors, autoantibody, T-cell immune response, Â-cell immune response, IgM and IgG.
[Back]