Authors: V.N. Zinovjeva, O.V. Ostrovsky

Address: Pharmacological Research Institute and Department of Pharmacology of Volgograd Medical Academy, 400066, Volgograd, Pavshikh Bortsov Sq., 1

Abstract:

Endogenous free radicals, in particular, reactive species of oxygen, nitrogen, chlorine cause DNA oxidation which is potentiated by exogenous prooxidant factors. The free radicals cause various DNA damages. This review highlights one of them, oxidative modification of guanosine, and also modern methods of the estimation of oxidized guanosine (8-oxodG) content. The numerous data on an induction of 8-oxodG in DNA by exogenous genotoxicants in vitro and in vivo are presented. 8-oxodG is used as a biomarker of DNA oxidation, accompanying some human diseases.

Key words: free radical, oxidative DNA damage, oxidized guanosine (8-oxodG), carcinogenesis, mutagenesis

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