|
Russian Journal | ISSN 0042-8809 |
| Voprosy Meditsinskoi Khimii | Biomedical Chemistry |
Issue:
Volume 48, issue 5
Title: Influence of GABA and pyracetam on mitochondrial ADP
phosphorylation system in conditions of experimental hypokinesia.
Authors: O.P.
Sotckiy, V.P. Hakopyan,L.G. Jamgaryan, A.G. Jamgaryan
Address: Department of
Pharmacology, Yerevan State Medical University
Abstract:
Long-term limitation of motor activity of male rats is accompanied by impairments of mitochondrial ADP phosphorylation in liver and heart. The most significant changes were observed after 15 and 45 days of hypokinesia. Administration of GABA and pyracetam to animals subjected to hypokinesia induced a tendency to "normalization" of ADP phosphorilation processes.
Key words: hypokinesia,
mitochondria, SDH, ADP, GABA, pyracetam.
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