Russian Journal

ISSN 0042-8809

Issue:
Volume 43, issue 3

Title:
BIOANTIOXIDANT ACTIVITY OF 3,5-DI-TERT-BUTYLPYROCATECHOL AND ITS INFLUENCE ON HYPOXIA, INFLAMMATION, PAIN AND BURNS

Authors:
O.I.Shaduro, G.N.Shilov, V.A.Timoschuk, V.I.Vlasova, A.S.Fedulov, N.I.Mezen

Address:
Belorussion State University, Minsk, Medical Institute, Minsk

Abstract:
The bioantioxidant activity of the synthesized by us on the base of the diatomic phenol compound - 3,5-di-t-butylpyrocatechol - has been studied. It was shown that this substance exhibits more pronounced antioxidant properties than tocopherol on the lipid peroxidation process in the rat brain homogenate appears in concentrations right up to 10^-8 - 10^-7 M. Antioxidant effect of 3,5-di-t-butylpyrocatechol protecting action correlation has been found in the simulation of such pathological organism states as hypoxia, inflammation, burn, pain. All above mentioned results confirms the expedience of search for new drugs based on diatomic phenols.

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