Russian Journal

ISSN 0042-8809

Issue:
Volume 43, issue 3

Title:
IDENTIFICATION PHYSICO-CHEMICAL PROPERTIES AND IMMUNOCHEMICAL CHARACTERISTIC OF PROSTATE SPECIFIC ANTIGEN AND ITS COMPLEXES WITH PROTEASE INHIBITORS

Authors:
V.P. Chekhonin², E.B. Mazo¹, I.A. Rjabukhin², M.E. Grigorev¹.

Address:
¹Russian State Medical University, Laboratory of Immunochemistry,
²Serbsky National Research Center for Social and Forensic Psychiatry, Moscow.

Abstract:
The study of the PSA complexes with the protease inhibitors has confimed the opinion of possible existence the complexies of the PSA with a2-macroglobulins and a1-antihymotripsines in blood serum. The immunoenzyme analysis of the PSA and its complexes has made it possible to establish the normal level of the PSA and corresponding complexes in donors blood serum. There are reasons to suppose, that the quantitative analysis of the PSA and its complexes with the protease inhibitors can be used for the early diagnosis of PC and its differential diagnosis with the prostate benign hyperplasia. In our opinion, the effect of the complex approach can be more informative than the ordinary PSA detection.

Key words:

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