Russian Journal

ISSN 0042-8809

Issue:
Volume 43, issue 3

Title:
INVOLVEMENT OF MONOAMINE OXIDASES IN FORMATION OF 4-HYDROXYPHENYLETHANOL, MAJOR COMPONENT OF TRIBULIN A.

Authors:
N.G. Panova, N.V.Veselovskaya, A.E. Medvedev

Address:
Institute of Biomedical Chemistry, Pogodinskaya str. 10, Moscow, 119832, fax: (095) 245-08-57

Abstract:
Pathways of 4-hydroxyphenylethanol formation were studied in the bovine brain. Incubation of brain homogenates with tyramine or tyrosine increased 4-hydroxyphenylethanol content only in the presence of NADH. Tyramine produced more pronounced augmentation of 4-hydroxyphenylethanol content than tyrosine. Tyrosine preparations were not contamined with tyramine. This suggests that 4-hydroxyphenylethanol may be formed from tyramine and tyrosine in NADH-dependent process. Preincubation of homogenates with 0.1 mM pargyline completely inhibited monoamine oxidases A and B and prevented NADH-dependent formatio n of 4-hydroxyphenylethanol from tyramine. The latter suggests that MAO is involved in formation of 4-hydroxyphenylethanol.

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