Russian Journal

ISSN 0042-8809

Issue:
Volume 43, issue 4

Title:
APPLICATION OF THE CHEMILUMINESCENT ASSAY FOR THE INVESTIGATION OF FREE FADICAL LIPID PEROXIDATION IN RAT BRAIN AFTER THE CRANIOCEREBRAL TRAUMA

Authors:
Promyslov M.Sh., Demchuk M.L., Poryadina L.V., Voronin V.G.

Address:
Burdenko Neurosurgical Institute, Fadeev str., 5, 125047 Moscow, Russia. FAX: 7 (095) 975-22-28

Abstract:
The method of chemiluminescence was applied for the determination of free radicals content in rabbit brain after the experimental craniocerebral trauma. The level of malone dialdehyde was measured spectrophotometrically. The quantity of free radical products in hemispheres, brain stem and cerebellum of rabbits with traumatic injury was shown to be significantly increased and correlated with MDA level. Data obtained indicate that the chemiluminescent technique can be useful for the investigation of lipid peroxidation in brain pathology.

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