Russian Journal

ISSN 0042-8809

Issue:
Volume 43, issue 4

Title:
THE INFLUENCE OF ORAL INULIN ADMINISTRATION ON FRUCTOSE-2,6-DIPHOAPHATE LEVEL IN LIVER OF RATS WITH STREPTOZOTOCIN DIABETES

Authors:
D.A.Guseva, V.K.Gorodetsly*, S.A.Kraevoi, M.S.Markova*, T.B.Tsyganjva

Address:
*Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Pogodinskaya str., 10, fax: (095) 245-0857
Moscow State Institute of Food Industry

Abstract:
The influence of oral inulin administration on glucose and fructose content in blood, glucose and ketone bodies in urine, and fructose-2,6-diphosphate content in liver was investigated in rats with streptozotocin diabetes. Short-term administration (during 5-6 days) of 0,5% inulin solution caused three-fold increase of blood fructose compared with control, normalisation of blood glucose and disappearance of glucose- and ketoneuria. The level of fructose-2,6-diphosphate in liver increased to the control level. Inulin administration during 12 days caused five-fold increase of blood fructose compares with control, glucose level increased up to the level of uncured diabetes (22 mmol/l), glucose- and ketoneuria appeared. The content of fructose-2,6-diphosphate in the liver decreased to diabetic level.

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