Russian Journal

ISSN 0042-8809

Issue:
Volume 43, issue 4

Title:
CYTOCHROME P450-DEPENDENT HYDROHYLATION AND ACTIVITY OF GLUTATHION-DEPENDENT LIVER ENZYMES IN PATIENTS WITH CHRONIC LIVER DISEASES

Authors:
Matyushin B.N., Loginov A.S., Tkachev V.D.

Address:
Central Research Institute of Gastroenterology, Moscow

Abstract:
Repression of cytochrome P450- dependent hydrohylation and demethylation in liver was demonstrated in bioptats of patients with chronic liver diseases. The inhibition of cytochrome P450 system was provoked by oxidative modification of proteins-enzymes in patients with chronic liver changes as was proposed at the same time. The activation of glutathione- dependent enzymes was revealed. So the intensification of conjugation and development processes was revealed as the compensation mechanisms of detoxication with chronic liver diseases.

Key words:

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