Russian Journal

ISSN 0042-8809

Issue:
Volume 43, issue 5

Title:
THE MOLECULAR PRINCIPLES FOR APPLICATIOM OF POLYAMINE ANALOGS AS INHIBITORS OF ENZYMES OF POLYAMINE SYNTHESIS ENZYMES

Authors:
T. T Berezov., T. V Fedoronchuk

Address:
Russian University of Peoples Friendship, Institute of General and Clinical Pathology at RUPF

Abstract:
Some physiological peculiarities of polyamines metabolism and new achievements in the study of molecular principles for application of inhibitors of polyamine biosynthesis as potent therapeutic agents against different diseases with altered cell proliferation, including cancer, are considered.

Key words: polyamine metabolism, inhibitors of polyamine biosynthesis, ornitine decarboxylase,polyamine oxidase