Russian Journal

ISSN 0042-8809

Issue:
Volume 43, issue 5

Title:
PROTEINS OF THE NUCLEAR MATRIX AND THEIR PHOSPHORYLATION IN NORMAL AND TUMOR CELLS

Authors:
I.B.Zbarsky

Address:
Koltsov Institute of Developmental Bioloqi Russian Academy of sciences, Moscow

Abstract:
The protein composition of the nuclear matrix of normal and tumor cells is discussed. A characteristic feature of the latter is the predominance of high molecular weight polypeptides containing mainly glyco- and phosphoproteins. Only few of them are identified. Nuclear matrix preparations from tumors differ by the presence of fibronectin and phosphotyrosine-containing proteins with a molecular mass of nearly 180 and 170 kDa as well as of high turnover of high molecular weight protein group and inhibition of their biosynthesis by chloramphenicol.

Key words: protein phosphorylation, nuclear matrix, normal and tumor cells