Russian Journal

ISSN 0042-8809

Issue:
Volume 43, issue 5

Title:
MOLECULAR-BIOLOGICAL ASPECTS OF THE INTERACTION OF THE NERVOUS AND IMMUNE SYSTEMS

Authors:
E.A.Korneva, O.I.Golovko, T.B.Kazakova.

Address:
Institute of Experimental Medicine, Russian Academy of Medical Sciences, St.-Petersburg, Russia.

Abstract:
The problem of the neuro-immuno interactions on the level of the protein trans-factors, stimulatinq interleukin-2 (IL-2) gene expression was discussed. The physico-chemical and funational parameters of the low molecular nuclear proteins (SP and BP- 14, 18, 19 kDs) isolated from splenic and brain cells of immunized rats were studied. The binding of these proteins to the regulatory region of IL-2 gene in vitro and stimulation of the IL-'2mRNA synthesis in splenic T-lymphocytes culture in normal conditions were shown. The protective effect of SP and BP on the IL-2mRNA synthesis in stressfull conditions and by the T-cells treatment with the CsA was demonstrated

Key words: nerwons and immune systems, qene, interleufin-2