Russian Journal

ISSN 0042-8809

Issue:
Volume 43, issue 5

Title:
THE ROLE OF IMMUNE INFLAMMNATION IN ATHEROGENESIS

Authors:
V. A. Nagornev, V. S. Rabinovich

Address:
Institute Experimental Medical RAMN St. Petersburg

Abstract:
Data on cellular-molecular aspects of the development of immune inflammation in vascular wall under atherogenesis are considered. Own results and literature data on the investigation of mechanism of adhesion of agrannulated leucocytes on endothelium, role of macrophages and T-cells in modification of apoprotein B-containing lipoproteins, production and secretion of proinflammatory cytokines and acute phage proteins by «intima» cells are considered. A conception evaluating atherogenesis as a local immune inflammation in the arterial wall is considered.

Key words: atherogenesis, immune inflammation, cytobines, modification of apoprotein B-confaining lipoproteins