Russian Journal

ISSN 0042-8809

Issue:
Volume 43, issue 5

Title:
BIOTECHNOLOGICAL DIRECTIONS IN THE DEVELOPMENT OF LIPID DRUGS AND DIAGNOSTIKS.

Authors:
V.I. Shvets,Yu.M. Krasnopolsky, A.P. Kaplun, A.E. Stepanov

Address:
Lomonosov State Academy of Fine Chemical Technology, Mosvcow

Abstract:
The paper summarizes own results of studies on phospholipids and glycolipids from natural biological sources. New approaches for synthesis of inositol-containing sphingophospholipids, glycophosphatidylinositols, semisynthetic synthesis of phosphoglycerols have been intriduced. New industrial method of phosphjatidylcholine isolation and production of number of lipid preparations were developed. Incorporation of DOPA into liposomes increases efficacy of its action in the medication of MPTP-induced parkinsonism in mice.

Key words: phospholipids, glycophospholipids, liposomes, biological membranes, biotechnology and lipid preparations