Russian Journal

ISSN 0042-8809

Issue:
Volume 44, issue 4

Title:
BLOCKADE OF SATURATED FATTY ACIDS TRANSPORT TO A CELL : PATHOGENESIS OF ESSENTIAL HYPERTENSION

Authors:
V.N.Titov

Address:
National Cardiology Research Centre, 3rd Cherepkovskaya str. 15-a. Moscow 122551 Russia, fax (095) 414 2962

Abstract:

Increased resistance to blood flow in arteries is built up by blockade of transport of saturated fatty acids of triglycerides in VLDL to cell through apoE/B-100 receptor endocythosis (active transport). This way does not affect the structure of cell membrane. blockade of the active transport stimulates the compensating activation of lipolysis increasing the level of free saturated fatty acids in the blood. These fatty acids are included into the cell membrane via passive transport. In the membrane fatty acids form local domains with unregulated permeability and nonspecific ion transport: Na⁺ and Ca²⁺ enter into cell without any control and K⁺ and Mg²⁺ leak out. Responding cells activate Na⁺, K⁺- and Ca²⁺ -ATPase and cholesterol synthesis. Ion pumps activate Na⁺ and Ca²⁺ out-fluxes; cholesterol blocks nonspecific ion permeability, but increases membrane microviscosity and inhibits secondary activity of ion pumps, thus forming vicious circle of hypernatriemia and hypercalciemia disturbing functions of loose conective tissue. They increase cell size, promote synthesis and secretion of collagen and elastin.lt has led to wail thickening, elasticity drop and artety clear cross section narrowing. The increase of sensitivity to contractility of smooth muscle cells, hyperreactivity towards pressor regulators and resistance to depressor regulators cause artery spasm, peripheral resistance increases and starts up pathogenesis of essential hypertension.

Key words: saturated and unsaturated free fatty acids, cholesterol, essentia hypertension.

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