Russian Journal

ISSN 0042-8809

Issue:
Volume 44, issue 5

Title:
THE INFLUENCE OF CYTOCHROME P450-DEPENDENT
ARACHIDONIC ACID METABOLITES I N REGULATION OF THE VASCULAR TONE

Authors:
KRZHECHKOVSKAYA V.V., NEBOLSIN V.E., ZHELTUKHINA G.A., EVSTIGNEEVA R.P., RUBTSOVA E.R.

Address:
Lomonosov Moscow State Academy of Fine Technologies.

Abstract:

The present paper reviews recent studies about the role of the cytochrome P-450-dependent arachidonic acid metabolites. There metabolites take part in the regulation of the vascular tone. They are the intracellular messenger and play an integral role in the relation of the vascular endothelium and smooth muscle cells. The arachidonic acid metabolites regulate the activity of the ionic channels. It is demonstrated that derivatives of arachidonic acid have the role in the pathogenesis of hypertension.

Key words: arachidonic acid metabolites, cytochrome P450, vascular tone.

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