Russian Journal

ISSN 0042-8809

Issue:
Volume 44, issue 5

Title:
NEW APPROACHES IN THE STUDY OF COMPLEMENT ALTERNATIVE PATHWAY SELF-REGULATION

Authors:
L.V.GALEBSKAYA

Address:
Saint-Petersburg State Pavlov Medical University

Abstract:
Experimental and literary data on the peculiarities of complement alternative pathway (APC) self- regulation and regulation are reviewed. There is a discussion of the methods of APC evaluation, including a new one, called complement hemolytical capacity. It is shown that the duration of complement- dependent hemolysis lag-period is limited by factor D concentration. The phenomenon of acceleration of APC-dependent hemolysis by membranes of lysed cells is described. The latter is an evidence of APC functioning in the mode of double amplification.

Key words: complement, self-regulation, blood serum.

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