Russian Journal

ISSN 0042-8809

Issue:
Volume 44, issue 6

Title:
AUTOANTIBODIES TO HUMAN BRAIN NMDA-RECEPTORS IN THE BLOOD OF THE PATIENTS WITH BRAIN STROKE

Authors:
T. V. DENISENKO1, D.I. SKULYABIN1, I. A. GROMOV1, YU.V. CHERKAS2, A.YU. ILYUCHINA3, S.A. DAMBINOVA

Address:
Institute of the Human Brain RAS1, Institute for Experimental Medicine RAMS2, Saint - Petersburg Medical University named after I.P.Pavlov3

Abstract:
Concentration of autoantibodies to human brain NMDA-receptor in blood serum of patients with acute brain ischemic stroke was significantly higher than in healthy persons and patients with other neurological diseases. Average content of cholesterol, lipid peroxides and glutamate in the serum were close in all patient groups investigated. It was suggested that the content of autoantibodies to human brain NMDA-receptor could be used as biochemical criteria for acute brain stroke patient’s condition control and their treatment efficiency.

Key words: autoantibodies, glutamate receptor, NMDA – receptor, acute brain ischemic stroke, Immunodiagnostics

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